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Effect of hydrogen peroxide on calcium homeostasis in smooth muscle cells

โœ Scribed by Antonella Roveri; Mariagrazia Coassin; Matilde Maiorino; Adriana Zamburlini; Frank Th.M. van Amsterdam; Emiliangelo Ratti; Fulvio Ursini


Book ID
115709315
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
586 KB
Volume
297
Category
Article
ISSN
0003-9861

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Lysyl oxidase (LO), an enzyme secreted by vascular smooth muscle cells (VSMC), initiates the covalent crosslinking of polypeptide chains within collagen and elastin. The present study reveals that purified LO strongly induces directional migration of VSMC in an in vitro assay system. LO-dependent ch