✦ LIBER ✦

Effect of hyaluronan on the elastase-type activity of human skin fibroblasts.

✍ Scribed by Emmanuelle Bernard; William Hornebeck; Ladislas Robert

Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 230 KB
Volume: 18
Category: Article
ISSN: 1065-6995
DOI: 10.1006/cbir.1994.1017

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✦ Synopsis

ABSTRACT

The influence of hyaluronan (HA) on the expression of human skin fibroblast elastase‐type protease (HSFEp) (Homsy et al, 1988) was studied. At confluency of HSF cultures, hyaluronan increased the level of HSFEp in a time and dose‐dependent fashion, Optimal effect was observed after 48 h of culture and at 2 mg/ml HA concentration; the stimulatory, effect of HA could be suppressed by 1 μM cycloheximide. The enhancement of enzyme biosynthesis by HA was dependent on cell proliferation but quasi invariant with HSF passage number (from 7‐21).

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