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Effect of heterogeneity and assumed mode of inheritance on lod scores

✍ Scribed by Durner, Martina ;Greenberg, David A.

Book ID
102702720
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
597 KB
Volume
42
Category
Article
ISSN
0148-7299

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✦ Synopsis

Heterogeneity is a major factor in many common, complex diseases and can confound linkage analysis. Using computer-simulated heterogeneous data we tested what effect unlinked families have on a linkage analysis when heterogeneity is not taken into account. We created 60 data sets of 40 nuclear families each with different proportions of linked and unlinked families and with different modes of inheritance. The ascertainment probability was 0.05, the disease had a penetrance of 0.6, and the recombination fraction for the linked families was zero. For the analysis we used a variety of assumed modes of inheritance and penetrances. Under these conditions we looked at the effect of the unlinked families on the lod score, the evaluation of the mode of inheritance, and the estimate of penetrance and of the recombination fraction in the linked families.

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