## Abstract The platelet‐derived growth factor (PDGF), which is found in serum but not in plasma, has been purified to homogeneity; it stimulates replication at a concentration of 10^−10^M. Brief treatment with PDGF causes densityinhibited Balb/c‐3T3 cells to become competent to synthesize DNA; pit
Effect of heparin-binding growth factors on monovalent cation transport in Balb/C 3T3 cells
✍ Scribed by José A. Halperin; Roy R. Lobb
- Book ID
- 117057676
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 423 KB
- Volume
- 144
- Category
- Article
- ISSN
- 0006-291X
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Biological effects of class 1 or class 2 heparin-binding growth factors (HBGFs) were compared in BALB/c-3T3 cells. Changes in protein synthesis, as monitored by two-dimensional gel electrophoresis, reveal that while both HBGFs induce the same changes in the synthesis of intracellular proteins, class
Heparan sulfate proteoglycans on the cell surface act as low affinity binding sites for acidic and basic fibroblast growth factor (FGF) [Moscatelli (1987): J Cell Physiol 131:123-1301 and play an important role in the interaction of FGF with the FGF receptor (FGFR). In this study, several aspects of