Effect of Growth Hormone on the Isolated Pancreatic Islets of Rat in vitro
✍ Scribed by MARTIN, JULIO M.; GAGLIARDINO, JUAN J.
- Book ID
- 109655518
- Publisher
- Nature Publishing Group
- Year
- 1967
- Tongue
- English
- Weight
- 226 KB
- Volume
- 213
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/213630a0
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Islet cell lines were produced by retroviral transduction of SV-40 T antigen to monolayer cultures of neonatal rat islets. One line, RN0-11, showed evolution of phenotypes in vitro. It evolved from a non-hormone secreting cell line to an insulin secreting line. It further developed glucagon producin
## Abstract Our objective was to study the effects of three (30, 40, and 50 mg/kg) doses of Streptozotocin (STZ) on fasting plasma glucose level (FPG) and observe its effects at the cellular level in rat pancreas by electron microscopy. FPG was measured in rats before induction of diabetes and then