The uptake of norepinephrine (NE) by human platelets at 10(-9)-5 X 10(-4) M of labelled amine concentration was investigated. At physiological concentrations of NE the uptake was unsaturable and could not be inhibited by imipramine or ouabain. At NE concentrations between 25 and 485 microM the uptak
Effect of formamidines on 5-hydroxytryptamine uptake and biogenic amine levels in rat platelets
β Scribed by Charles O. Knowles; Terry L. Johnson
- Book ID
- 107937382
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 397 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0300-483X
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In order to elucidate the metabolic modifications induced in rat brain by low power He-Ne laser irradiation in vivo, the variations in the biogenic amine levels in cortex, striatum and hippocampus were studied. Noradrenaline (NA), dopamine (DA) and serotonin (5-HT) were evaluated by HPLC-EC on irrad
Platelets of healthy smokers and nonsmokers were prepared and their content of 5-hydroxytryptamine was determined by HPLC with electrochemical detection. Platelet 5-HT levels in smokers (728 \_+ 156 pmol per 10 s platelets, mean\_+ SEM, n=9) were significantly higher than those in non-smokers (353\_