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Effect of Experimental Temperature on the Permeation of Model Diffusants Across Porcine Buccal Mucosa

โœ Scribed by Upendra Dilip Kulkarni; Ravichandran Mahalingam; Xiaoling Li; Indiran Pather; Bhaskara Jasti

Book ID
111768358
Publisher
Springer US
Year
2011
Tongue
English
Weight
244 KB
Volume
12
Category
Article
ISSN
1530-9932

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๐Ÿ“œ SIMILAR VOLUMES

Porcine buccal mucosa as in vitro model:
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Porcine buccal mucosa has been used as an in vitro model to assess the potential of delivering a molecule via the transbuccal route. However, permeation studies across porcine buccal mucosa show high variability due to various experimental and biological factors. The variability associated with the

Effect of thermodynamic activities of th
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The objective of this work was to delineate the contribution of thermodynamic activities of ionized and unionized species on buccal drug permeation. The flux and permeability of a model acidic (nimesulide) and basic (bupivacaine) drug were determined across porcine buccal mucosa at different pH cond