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Effect of exogenous E2F-1 on the expression of common chromosome fragile site genes, FHIT and WWOX

โœ Scribed by Hideshi Ishii; Koshi Mimori; Andrea Vecchione; Krittaya Sutheesophon; Toshiyoshi Fujiwara; Masaki Mori; Yusuke Furukawa

Book ID
116288137
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
944 KB
Volume
316
Category
Article
ISSN
0006-291X

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Expression of common chromosomal fragile
Expression of common chromosomal fragile site genes, WWOX/FRA16D and FHIT/FRA3B is downregulated by exposure to environmental carcinogens, UV, and BPDE but not by IR
โœ Elangovan Thavathiru; John H. Ludes-Meyers; Michael C. MacLeod; C. Marcelo Aldaz ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 204 KB

Common chromosomal fragile sites are unstable genomic loci susceptible to breakage, rearrangement, and are highly recombinogenic. Frequent alterations at these loci in tumor cells led to the hypothesis that they may contribute to cancer development. The two most common chromosomal fragile sites FRA1