𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of ethanol on GABA uptake and release from hypothalamic fragments

✍ Scribed by Adriana Seilicovich; Beatriz H. Duvilanski; Mercedes Lasaga; Luciano Debeljuk; María del Carmen Díaz

Publisher
Springer
Year
1988
Tongue
English
Weight
560 KB
Volume
95
Category
Article
ISSN
0033-3158

No coin nor oath required. For personal study only.

✦ Synopsis

A study was performed on the effect of ethanol on the basal and K +-evoked efflux of endogenous GABA from rat hypothalamic fragments. The amount of GABA present in the medium and in the tissue was measured by radioreceptor assay. In vitro addition of ethanol (50 and 100 mM) enhanced the K+-evoked efflux of GABA in a Ca + r-dependent manner, and increased tissue GABA content. Since K +-evoked outflow induced by ethanol was not affected by the presence of nipecotic acid, ethanol appears to alter the uptake of endogenous GABA. An inhibitory effect of ethanol on 3H-GABA uptake was observed under K + depolarization. On the other hand, acute ethanol administration produced a decrease in basal and K+-evoked efflux from hypothalamic fragments and in tissue GABA concentration. Changes in GABA efflux may lie behind some of the neuropharmacological effects of ethanol.

📜 SIMILAR VOLUMES

Release of Adenosine from Human Sensitiz
Release of Adenosine from Human Sensitized Lung Fragments and its Effect on Antigen-induced Mediator Release
✍ K. Konnaris; H.G.E. Lloyd; D.M. Temple 📂 Article 📅 1996 🏛 Elsevier 🌐 English ⚖ 153 KB

Adenosine may play a role in asthma as a pro-inflammatory mediator. In this study, the release of adenosine from human sensitized lung fragments and its effect on antigen-induced histamine and leukotriene release has been explored. Antigen challenge increased histamine and leukotriene release five-f