Effect of Epstein–Barr virus infection on global gene expression in nasopharyngeal carcinoma
✍ Scribed by Yuan-Chii Gladys Lee; Yu-Chyi Hwang; Kuang-Chi Chen; Yong-Shiang Lin; Dah-Yeou Huang; Tao-Wei Huang; Cheng-Yan Kao; Han-Chung Wu; Chin-Tarng Lin; Chi-Ying F. Huang
- Book ID
- 106283300
- Publisher
- Springer-Verlag
- Year
- 2006
- Tongue
- English
- Weight
- 638 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1438-793X
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## Abstract We have investigated the association of immunoescape mechanisms in nasopharyngeal carcinoma (NPC) lesions with Epstein‐Barr virus (EBV) infection and clinical course of the disease. Tumor biopsy specimens obtained from 36 Japanese NPC patients were examined for antigen processing machin
Cases of nasopharyngeal carcinoma (NPC) from North Africa show an unusual bimodal age distribution. As elsewhere, the tumor is closely associated with the presence of Epstein-Barr virus (EBV). The expression of EBV genes and c-onc genes was studied i n biopsy specimens from tumors at different clini
## RESULTS. In specimens from 107 patients with NPC, EBV was detected by PCR in 2 Department of Pathology, the Johns Hopkins 97 cases (90.7%) and by EBER in situ hybridization in 105 cases (98.1%). In speci-