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Transcriptional expression of Epstein-Barr virus genes and proto-oncogenes in North African nasopharyngeal carcinoma

✍ Scribed by Sbih-Lammali, F.; Djennaoui, D.; Belaoui, H.; Bouguermouh, A.; Decaussin, G.; Ooka, T.

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
931 KB
Volume
49
Category
Article
ISSN
0146-6615

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✦ Synopsis

Cases of nasopharyngeal carcinoma (NPC) from North Africa show an unusual bimodal age distribution. As elsewhere, the tumor is closely associated with the presence of Epstein-Barr virus (EBV). The expression of EBV genes and c-onc genes was studied i n biopsy specimens from tumors at different clinical stages from 11 young (10 to 30-year-old) and 11 adult (30 t o 65-yearold) patients. It was found that the two age groups do not differ in their pattern of gene expression, that there is a tendency for later stage biopsies to express more viral and c-onc transcripts, and that samples expressing larger numbers of EBV genes also tend to express many different c-onc specificities.

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