Effect of epinephrine on local cutaneous blood flow

✍ Scribed by Larrabee, Wayne F. ;Lanier, Brent J. ;Miekle, David

• Publisher: Wiley (John Wiley & Sons)
• Year: 1987
• Weight: 286 KB
• Volume: 9
• Category: Article
• ISSN: 0148-6403
• DOI: 10.1002/hed.2890090507

✦ Synopsis

Quantification of the effect of subcutaneous infiltration of saline with epinephrine and of lidocaine with epinephrine on local cutaneous blood flow was accomplished utilizing the laser Doppler method. A comparison of the onset of vasoconstriction, rnagnitude of diminished blood flow, and duration of effect was made for several commonly used concentrations of epinephrine. Injected solutions containing epinephrine in concentrations of 1 : 200,000 and higher offered good vasoconstrictor effects when both the magnitude and duration of flow reduction were considered. There was a significant (P = 0.0001) difference in flow between epinephrine concentrations of 1 :400,000 and all others. There were no significant differences (P > 0.05) between con-