Effect of enzyme inducers and inhibitors on the pharmacokinetics of oltipraz in rats
โ Scribed by Soo Kyung Bae; Shin Jung Lee; Young Hoon Kim; Taekrho Kim; Myung Gull Lee
- Book ID
- 111769533
- Publisher
- Pharmaceutical Press
- Year
- 2005
- Tongue
- English
- Weight
- 184 KB
- Volume
- 57
- Category
- Article
- ISSN
- 2042-7158
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๐ SIMILAR VOLUMES
Pharmacokinetic parameters of oltipraz were compared after intravenous and oral administration at a dose of 30 mg/kg to control rats and rats with U-ARF. After intravenous administration to rats with U-ARF, the AUC was significantly greater (1100 versus 1730 mg ร min/mL) than that in control rats, a
Pharmacokinetic parameters of oltipraz were compared after intravenous (10 mg/kg) and oral (50 mg/kg) administration to control male Sprague-Dawely rats and mutant Nagase analbuminemic rats (NARs). In NARs, the expression and mRNA level of CYP1A2 increased, and oltipraz was mainly metabolized via CY