Effect of Dynamic Channelling on the Transient-state Kinetics of Coupled Enzyme Reactions
โ Scribed by G. Pettersson
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 121 KB
- Volume
- 198
- Category
- Article
- ISSN
- 0022-5193
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โฆ Synopsis
Evidence is presented to show that the presence of a channelled reaction branch in a coupled two-enzyme reaction leads to a slower overall relaxation of the system towards steady state following perturbations of the reaction conditions. A predominant part of the total reaction flux change resulting from perturbations may be governed by transients that are more rapid in the presence than in the absence of a channel, but only under specific conditions that are not likely to be of biological relevance.
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