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Effect of Dynamic Channelling on the Transient-state Kinetics of Coupled Enzyme Reactions

โœ Scribed by G. Pettersson


Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
121 KB
Volume
198
Category
Article
ISSN
0022-5193

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โœฆ Synopsis


Evidence is presented to show that the presence of a channelled reaction branch in a coupled two-enzyme reaction leads to a slower overall relaxation of the system towards steady state following perturbations of the reaction conditions. A predominant part of the total reaction flux change resulting from perturbations may be governed by transients that are more rapid in the presence than in the absence of a channel, but only under specific conditions that are not likely to be of biological relevance.


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