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Effect of deuterium oxide on the saprophytic culture of Claviceps II. Alkaloid production

✍ Scribed by R. G. Mrtek; H. L. Crespi; M. I. Blake; J. J. Katz

Publisher
John Wiley and Sons
Year
1967
Tongue
English
Weight
549 KB
Volume
56
Category
Article
ISSN
0022-3549

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Effect of deuterium oxide on the culturi
Effect of deuterium oxide on the culturing of Penicillium janczewskii II. Isolation of fully deuterated griseofulvin
✍ D. A. Nona; M. I. Blake; H. L. Crespi; J. J. Katz πŸ“‚ Article πŸ“… 1968 πŸ› John Wiley and Sons 🌐 English βš– 606 KB

Fully deuterated griseofulvin was isolated in pure form from P. janczewskii grown in a completely deuterated medium. Direct fermentation and a replacement culture technique were used. The isolated antibiotic was purified by thin-layer chromatography and characterized by ultraviolet, infrared, and nu