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Effect of deuterium oxide on the culturing of Penicillium janczewskii II. Isolation of fully deuterated griseofulvin

โœ Scribed by D. A. Nona; M. I. Blake; H. L. Crespi; J. J. Katz

Publisher
John Wiley and Sons
Year
1968
Tongue
English
Weight
606 KB
Volume
57
Category
Article
ISSN
0022-3549

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โœฆ Synopsis

Fully deuterated griseofulvin was isolated in pure form from P. janczewskii grown in a completely deuterated medium. Direct fermentation and a replacement culture technique were used. The isolated antibiotic was purified by thin-layer chromatography and characterized by ultraviolet, infrared, and nuclear magnetic resonance spectra. The extent of incorporation of deuterium during biosynthesis at the various proton sites in the molecule was determined.

N A PREVIOUS PAPER (1) the effect of heavy biotic was reported. Nutritional requirements I water both on the growth of the mold Penicil-for optimal growth in D20 and the general culture lizim janczmskii and on its production of anti-techniques were described in detail. Griseofulvin production was severely impaired when the

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