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Effect of dantrolene sodium on calcium movements in single muscle fibres

✍ Scribed by HAINAUT, KARL; DESMEDT, JOHN E.

Book ID
109693858
Publisher
Nature Publishing Group
Year
1974
Tongue
English
Weight
333 KB
Volume
252
Category
Article
ISSN
0028-0836

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To examine whether a decrease in cytosolic Ca 2+ affects fibrillation potentials, we studied effects of dantolene on these potentials in denervated rat muscle. Administered intraperitoneally, dantrolene sodium (12-22 mg/kg) abolished fibrillation potentials and subthreshold oscillating potentials ov