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Effects of dantrolene sodium on fibrillation potentials in denervated rat muscles

✍ Scribed by Shin-Ichi Izumi; Akio Tsubahara; Naoichi Chino; Kiyoshi Mineo

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 108 KB
Volume: 21
Category: Article
ISSN: 0148-639X
DOI: 10.1002/(sici)1097-4598(199812)21:12<1797::aid-mus28>3.0.co;2-5

No coin nor oath required. For personal study only.

✦ Synopsis

To examine whether a decrease in cytosolic Ca 2+ affects fibrillation potentials, we studied effects of dantolene on these potentials in denervated rat muscle. Administered intraperitoneally, dantrolene sodium (12-22 mg/kg) abolished fibrillation potentials and subthreshold oscillating potentials over 2.5-6 h without affecting excitability of the muscle to electrical stimulation. Fibrillation potentials reappeared 36-96 h after administration of dantrolene. We suggest that cytosolic Ca 2+ has a specific role in generating fibrillations.

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