The effect of prostacyclin on canine hepatic bile flow was evaluated. Utilizing chronic, unanesthetized bile fistula dogs, prostacyclin was found to significantly increase bile flow rates and bile bicarbonate and cyclic AMP concentration and output when compared to control values. The choleretic res
Effect of cyclosporine and steroids on canine bile flow
β Scribed by John J. Brems; Jeffery Reese; Robert Kane III; Donald L. Kaminski
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 590 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
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Abbreviations: AUC, area under the curve; AUC 0-1 , area under the curve from time 0 to infinity; CI, confidence interval(s); CL/F, apparent clearance; C max , maximum concentration; CRU, Clinical Research Unit; CYP3A, cytochrome P450 3A; DN, dose-normalized; F, oral bioavailability; GLS mean ratio(
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