Etoposide was incorporated in an injectable parenteral emulsion, in an attempt to alter its pharmacokinetics and improve anticancer activity. Parenteral emulsion of etoposide (EPE), which remained stable over 6 months' storage, was prepared (under optimal experimental conditions) using soybean oil a
Effect of cyclosporine A on the tissue distribution and pharmacokinetics of etoposide
✍ Scribed by Jaime Cárcel-Trullols; Francisca Torres-Molina; Amparo Araico; Anas Saadeddin; José Esteban Peris
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 251 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0344-5704
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Abbreviations: AUC, area under the curve; AUC 0-1 , area under the curve from time 0 to infinity; CI, confidence interval(s); CL/F, apparent clearance; C max , maximum concentration; CRU, Clinical Research Unit; CYP3A, cytochrome P450 3A; DN, dose-normalized; F, oral bioavailability; GLS mean ratio(
The effects of the local vasoconstrictor phenylephrine on the dermal absorption kinetics and local tissue distribution of compounds were investigated in rats. Phenylephrine (0.0025% -0.1%) and tracer quantities of salicylic acid, lidocaine, and water were applied in an aqueous solution to the expose