Effect of cupric-isonicotinic acid hydrazide complex on avian myeloblastosis virus reverse transcriptase and its associated enzyme activities
โ Scribed by M. B. Vasudevachari; A. Antony
- Book ID
- 112831428
- Publisher
- Indian Academy of Sciences
- Year
- 1985
- Tongue
- English
- Weight
- 905 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0250-5991
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The inhibitor captan (N-trichloromethylthio-4-cyclohexen-1,2-dicarboximide) was used to explore the ribonuclease H (RNase H) active site of avian myeloblastosis virus (AMV) reverse transcriptase. Gel permeation chromatography of purified enzyme showed that [14C]captan bound to the alpha subunit in a
The Copper complex of the antituberculous drug, isonicotinic acid hydrazide CINH). inhibits the RNA-dependent DNA polymerase of ROW sarcoma virus and inactivates its ability to malignantly transform chick embryo cells. The INH-copper complex binds to the 70s genome RNA of ROW sarcoma virus (RSV). wh