## Abstract The glycerol fedโbatch fermentation by __Klebsiella pneumoniae__ CGMCC 1.6366 exhibited the sequential synthesis of products, including acetate, 1,3โpropanediol (1,3โPD), 2,3โbutanediol, ethanol, succinate, and lactate. The dominant flux distribution was shifted from acetate formation t
Effect of culture conditions on 3-hydroxypropionaldehyde detoxification in 1,3-propanediol fermentation by Klebsiella pneumoniae
โ Scribed by Zong-Ming Zheng; Ke-Ke Cheng; Qiu-Long Hu; Hong-Juan Liu; Ni-Ni Guo; De-Hua Liu
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 423 KB
- Volume
- 39
- Category
- Article
- ISSN
- 1369-703X
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## Abstract __Klebsiella pneumoniae__ HR526, a new isolated 1,3โpropanediol (1,3โPD) producer, exhibited great productivity. However, the accumulation of lactate in the lateโexponential phase remained an obstacle of 1,3โPD industrial scale production. Hereby, mutants lacking Dโlactate pathway were
## Abstract **BACKGROUND:** Glycerol dehydrogenase [EC.1.1.1.6] and 1,3โpropanediol oxidoreductase [EC.1.1.1.202] were proved to be two of the key enzymes for glycerol conversion to 1,3โpropanediol in __Klebsiella pneumoniae__ under anaerobic conditions. For insight into their significance on 1,3โp
The initial steps of glycerol dissimilation and 1,3-propanediol (1,3-PD) formation by Klebsiella pneumoniae anaerobically grown on glycerol were studied by quantifying the in vitro and in vivo activities of enzymes in continuous culture under conditions of steady state and oscillation and during tra