Effect of cordycepin on the replication of type-c rna tumor viruses

✍ Scribed by L. S. Richardson; R. C. Ting; R. C. Gallo; A. M. Wu

• Publisher: John Wiley and Sons
• Year: 1975
• Tongue: French
• Weight: 465 KB
• Volume: 15
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910150311

✦ Synopsis

Abstract

Cordycepin (3′‐deoxyadenosine) was previously shown to inhibit virus production induced by iododeoxyuridine from murine fibroblasts (Wu et al., 1972). We now report that the inhibitory effect of cordycepin results in a reduction of the number of cells producing virus as measured by the infectious center assay and fluorescent antibody technique. Cordycepin has a much greater inhibitory effect on viral replication than on transformation of normal rat kidney cells by murine sarcoma virus since viral production was greatly reduced (seven‐ to 35‐fold) with 5–10 μg/ml of cordycepin while viral transformation was only slightly inhibited (two‐fold reduction in focus‐forming units) with the same concentration of cordycepin. Inhibition of viral production is most effective if the compound is present during the first 24 h after infection.