Effect of complex formation on drug absorption IX: Determination of the intestinal transfer rate constant of the salicylamide-caffeine complex

✍ Scribed by Richard H. Reuning; Gerhard Levy

• Publisher: John Wiley and Sons
• Year: 1969
• Tongue: English
• Weight: 564 KB
• Volume: 58
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600580116

✦ Synopsis

A model describing the overall transfer of a drug across biologic membranes in the presence of a complexing agent is presented. This model has been applied to the transfer of salicylamide across the cannulated everted intestine of the rat in the presence of caffeine. Assuming that (a) salicylamide and the salicylamide-caffeine complex are transferred at a rate proportional to their respective concentration gradient, and (b) the complex is not dissociated at the surface of the absorbing membrane, it is shown that k a p p . l k s n r n . = k c r n o p l e x l k ~a m . + Ff (1k c o m p l e x l k s a m . ) , where

In the context used in this paper, "overall" refers to the combined effect or behavior of free and complexed drug.