Effect of cimetidine and probenecid on pilsicainide renal clearance in humans
โ Scribed by SHIGA, T; HASHIGUCHI, M; URAE, A; KASANUKI, H; RIKIHISA, T
- Book ID
- 111726731
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 62 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0009-9236
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Ranitidine renal clearance was investigated in the beagle dog with or without concomitant infusion of cimetidine or probenecid. Ranitidine was excreted mainly by renal tubular secretion. Plasma clearance was reduced by probenecid from 198 9 47 to 119 9 41 mL min -1 (mean9 S.D.); renal clearance was
In a randomized, double-blind, cross-over experiment, 6 healthy consenting male subjects were administered cimetidine 600 mg or ranitidine 300 mg or placebo p.o. q12h x 2 days. Nicotine bitartrate was administered i.v. on day 2 (1 microgram/kg/min) x 30 min. After cimetidine mean nicotine total and