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Effect of chronic ethanol administration on drug metabolism in isolated hepatocytes with emphasis on paracetamol activation

✍ Scribed by P. Moldéus; B. Andersson; A. Norling; K. Ormstad

Book ID
115775010
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
507 KB
Volume
29
Category
Article
ISSN
0006-2952

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✍ Hannu Väänänen; Mikko Salaspuro; Kai Lindros 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 597 KB

Periportal (pp) and perivenous (pv) hepatocyte populations were separated using a two-directional closed perfusion technique with selective addition of collagenase either to direct or retrograde perfusions (Väänänen, H. et al., Liver 1983; 3:131). The activity of GPT in hepatocytes from the pp-area