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Effect of chelating agents upon the synthesis of nucleic acids and protein: Inhibition of DNA synthesis by 1-formylisoquinoline thiosemicarbazone

✍ Scribed by Alan C. Sartorelli


Book ID
119404698
Publisher
Elsevier Science
Year
1967
Tongue
English
Weight
306 KB
Volume
27
Category
Article
ISSN
0006-291X

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o Molephantinin, a germacranolide, has previously been shown to possess antineoplastic activity in rodents. The principle effect of molephantinin on Ehrlich ascites carcinoma cells was to depress DNA and protein synthesis both in uiuo and in uitro. DNA synthesis was inhibited a t the following sites