Antitumor agents LII: The effects of molephantinin on nucleic acid and protein synthesis of ehrlich ascites cells

✍ Scribed by Iris H. Hall; Y. F. Liou; K. H. Lee

• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 551 KB
• Volume: 71
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600710620

✦ Synopsis

o Molephantinin, a germacranolide, has previously been shown to possess antineoplastic activity in rodents. The principle effect of molephantinin on Ehrlich ascites carcinoma cells was to depress DNA and protein synthesis both in uiuo and in uitro. DNA synthesis was inhibited a t the following sites: DNA polymerase, purine synthesis specifically a t inosinic acid dehydrogenase and to a lesser degree a t dihydrofolate reductase, Pyrimidine synthesis a t orotidine monophosphate decarboxylase, thymidine kinase, histone phosphorylation, and oxidative phosphorylation processes. The protein synthesis inhibition pattern resembled more an initiation inhibitor as opposed to an elongation inhibitor.

Keyphrases Molephantinin-effects on nucleic acid and protein synthesis of Ehrlich ascites cells 0 Antitumor agents-effects of molephantinin on nucleic acid and protein synthesis of Ehrlich ascites cells 0 DNA-synthesis. effects of molephantinin, Ehrlich ascites cells 0 RNA-synthesis, effects of molephantinin, Ehrlich ascites cells 0 Protein synthesis-effects of molephantinin, Ehrlich ascites cells Hyamine Hydroxide, New England Nuclear.