Effect of cancer chemotherapy on dapsone N-acetylation in man

✍ Scribed by P. A. Philip; P. G. Harper; H. J. Rogers

• Book ID: 104772188
• Publisher: Springer
• Year: 1989
• Tongue: English
• Weight: 166 KB
• Volume: 23
• Category: Article
• ISSN: 0344-5704
• DOI: 10.1007/bf00435844

✦ Synopsis

The effect of cancer chemotherapy on dapsone (DDS) N-acetylation was explored in 28 patients with various malignancies. There was a significant (P = 0.01) increase in plasma monoacetydapsone/dapsone (MADDS/ DDS) ratios within 24 h of the start of chemotherapy (CT), indicating an acceleration of N-acetylation.