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Effect of nucleotide substitutions in N-acetyltransferase-1 on N-acetylation (deactivation) and O-acetylation (activation) of arylamine carcinogens: implications for cancer predisposition

✍ Scribed by Adrian J. Fretland; Mark A. Doll; Yuanqi Zhu; Leo Smith; Matthew A. Leff; David W. Hein

Book ID
114238054
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
138 KB
Volume
26
Category
Article
ISSN
0361-090X

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Effects of single nucleotide polymorphis
Effects of single nucleotide polymorphisms in human N-acetyltransferase 2 on metabolic activation (O-acetylation) of heterocyclic amine carcinogens
✍ David W. Hein; Adrian J. Fretland; Mark A. Doll 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 79 KB

## Abstract N‐Acetyltransferase 2 (NAT2) catalyzes the O‐acetylation of N‐hydroxy heterocyclic amines such as N‐hydroxy‐2‐amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline (NOHMeIQx) and N‐hydroxy‐2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b] pyridine (NOH PhIP) to DNA binding metabolites that initiate mut