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Effect of bryostatin 1 on drug-induced, topoisomerase II-mediated DNA cleavage and topoisomerase 11 gene expression in human leukemia cells

โœ Scribed by Leonard A. Zwelling; Diana Chan; Elizabeth Altschuler; Janice Mayes; Michael Hinds; George R. Pettit


Book ID
115782024
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
645 KB
Volume
41
Category
Article
ISSN
0006-2952

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Topoisomerase II (TopoII) is a Mg-dependent enzyme involved in topological modifications of DNA that are crucial to the regulation of cell proliferation and possibly differentiation. To investigate the role of Mg availability in the modulation of TopoII in whole cells, we studied enzyme activity and