𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The effect of staurosporine on drug-induced, topoisomerase II-mediated DNA cleavage in human leukemia cells

✍ Scribed by Leonard A. Zwelling; Elizabeth Altschuler; Janice Mayes; Michael Hinds; Diana Chan


Publisher
Springer
Year
1991
Tongue
English
Weight
490 KB
Volume
29
Category
Article
ISSN
0344-5704

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Effect of extracellular magnesium on Top
✍ Valeria Covacci; Nicodemo Bruzzese; Alessandro Sgambato; Ram Ganapathi; Achille πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 200 KB πŸ‘ 2 views

Topoisomerase II (TopoII) is a Mg-dependent enzyme involved in topological modifications of DNA that are crucial to the regulation of cell proliferation and possibly differentiation. To investigate the role of Mg availability in the modulation of TopoII in whole cells, we studied enzyme activity and

Effects of tumor necrosis factor, alone
✍ Giuseppe Giaccone; Chikabumi Kadoyama; Rhoda Maneckjee; David Venzon; Richard B. πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 French βš– 418 KB

## Abstract Tumor necrosis factor Ξ± (TNF) exhibits cytotoxic activity on some solid tumors and has been reported to be synergistic with topoisomerase‐II‐targeted antineoplastic agents. A wide range of TNF concentrations (from 10 to 10,000 U/ml) was tested in 9 human lung cancer cell lines (5 small‐

Effect of arsenic and cadmium on the per
✍ Andreas Hartmann; GΓΌnter Speit πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 658 KB

The alkaline single cell gel electrophoresis (SCG test or comet assay) was used to characterize the influence of sodium arsenite (NaAsO?) and cadmium sulphate (CdS04) on the persistence of mutagen-induced DNA lesions. Human blood and SV40transformed fibroblasts (MRCSCVI ) were treated for 2 hr with

Effect of camptothecin on mitogenic stim
✍ Silvia Bruno; Walter Giaretti; Zbigniew Darzynkiewicz πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 929 KB

The possible involvement of DNA topoisomerase I in cell transition from C , to G , and in progression through the cell cycle was studied by estimating the ability of human peripheral blood lymphocytes to undergo mitogenic stimulation in the presence of the topoisomerase I inhibitor camptothecin (CAM