𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Effect of bacillus calmette-guéarin cell wall skeleton on the induction of the cytotoxic and suppressor T cells against syngeneic tumor in the mouse

✍ Scribed by Shohei Koyama; Shigeyoshi Fujimoto; Tomio Tada; Takao Sakita

Publisher
John Wiley and Sons
Year
1981
Tongue
French
Weight
642 KB
Volume
27
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The effect of Bacillus Calmette‐Guérin cell wall skeleton (BCG‐CWS), which is one of the well‐established immunopotentiators, on the induction of either cytotoxic or suppressor T cells against syngeneic tumor S1509a was investigated by an in vitro assay system. BCG‐CWS showed an apparent augmenting activity in the induction of cytotoxic T cells against a syngeneic tumor when it was administered subcutaneously into mice with mitomycin C (MMC)‐treated tumor cells in a form of oil‐in‐water emulsion. In addition, cytotoxic T cell activity was dominantly generated in regional lymph nodes. Furthermore, the immunized animals developed stronger resistance against the second inoculum of the same viable tumor cells. However, BCG‐CWS had no effect on the induction of suppressor T cells in tumor‐bearing host (TBH), and could not induce cytotoxic T cells against the homologous tumor in TBH in which suppressor T cells had been readily activated. The growth of tumor was neither suppressed nor enhanced, even if an oil‐attached BCG‐CWS was administered in TBH.

📜 SIMILAR VOLUMES

Separation of lymphoid cells with a supp
Separation of lymphoid cells with a suppressor effect on the activity of cytotoxic cells in vitro during the growth of a syngeneic mouse tumour
✍ N. Schaaf-Lafontaine 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 French ⚖ 487 KB 👁 2 views

## Abstract One or 4 weeks after grafting of a syngeneic sarcoma (T~2~) to C57BL/6 mice, lymph‐node cells (LNC) are cytotoxic __in vitro__ for the cells of this tumour. But after 2 weeks LNC are not cytotoxic or show a non‐significant activity. These second‐week LNC, added to cytotoxic lymphocytes

Non-H-2-associated genetic regulation of
Non-H-2-associated genetic regulation of cytotoxic responses to hapten-modified syngeneic cells Effect on the magnitude of secondary response and helper T cell generation after in vivo priming
✍ Hiromi Fujiwara; Gene M. Shearer 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 523 KB

## Abstract The present study investigates the role of non‐H‐2 genes in controlling generation of the H‐2‐restricted, T cell‐mediated cytotoxic response against trinitrophenyl (TNP)‐modified syngeneic cells (TNP‐self). Spleen cells from C3H/He (H‐2^k^) or B10.BR (H‐2^k^) normal mice or from mice pr