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Effect of ascorbic acid on humoral and other factors of immunity in coal-tar exposed workers

✍ Scribed by Lubomír Dobiáš; Ivo Lochman; Jan Machálek; Radim Šrám

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
245 KB
Volume
6
Category
Article
ISSN
0260-437X

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✦ Synopsis

A group of 30 coal-tar workers was treated with 1 g of ascorbic acid (AA) orally five times a week for 3 months. The effect of this treatment was assessed on serum IgG, IgM, IgA, aI-entitrypsin, prealbumin, orosomucoid, transferrin, az-macroglobulin, C-reactive protein, ceruloplasmin, the latex fixation test and cancer serum index (CSI). After 3 months treatment the concentration of AA in the blood increased from 9.52 to 60.75 pmol I-' (i.e. from 0.15 to 1.07 mg 100 ml-'), prealbumin increased from 0.37 f 0.08 g 1-' to 0.48 f 0.08 g I-' (P < 0.01), CSI decreased from 2.28 f 0.88 to 1.76 f 0.50 (P < 0.01) and a2-macroglobulin decreased from 3.40 f0.95 to 2.06 f 0.39 g I-' (P < 0.01). These findings, together with reports that AA is a strong stimulatcr of xenobiotics biotransformation in the liver, support the use of AA as a prophylactic agent for coal-tar exposed workers.

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## Abstract Insulin‐like growth factor 1 (IGF‐1) and its major binding protein, IGF binding protein 3 (IGFBP‐3) are implicated in lung cancer and other malignancies. We have previously shown that the combination of three major antioxidants [β‐carotene (BC), α‐tocopherol (AT) and ascorbic acid (AA)]