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The effects of phenytoin, 5-(para-hydroxyphenyl)-5-phynylhydantoin and valproic acid on humoral immunity in mice

✍ Scribed by Mary L. de Souza Queiroz; P.W. Mullen

Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
86 KB
Volume
2
Category
Article
ISSN
0192-0561

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Effect of 5-(p-hydroxyphenyl)-5-phenylhydantoin (p-HPPH) enantiomers, major metabolites of phenytoin, on the occurrence of chronic-gingival hyperplasia: in vivo and in vitro study
✍ I. Ieiri; W. Goto; S. Higuchi; K. Hirata; A. Toshitani; S. Imayama; Y. Ohyama; H πŸ“‚ Article πŸ“… 1995 πŸ› Springer 🌐 English βš– 571 KB

The purpose of this study was to assess the possible role of the (R)-and (S)-enantiomers of the phenytoin metabolite p-HPPH in the pathogenesis of gingival hyperplasia (GH). About 98% of circulating p-HPPH is in the (S)-form. There were significant differences between patients with and without GH in