Effect of apoptotic and proliferative indices, P-glycoprotein and survivin expression on prognosis in laryngeal squamous cell carcinoma
β Scribed by Da-Wei Li; Shang Gao; Bin Shen; Pin Dong
- Book ID
- 107577300
- Publisher
- Springer US
- Year
- 2010
- Tongue
- English
- Weight
- 499 KB
- Volume
- 28
- Category
- Article
- ISSN
- 1357-0560
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## Abstract ## Background Proteins regulating the cell cycle and cell death are frequently abnormally expressed in cancer. Several of these, particularly p53 and Bclβ2, have been widely suggested as possible prognostic markers in diverse human malignancies. Their role in predicting outcome in squa
We investigated immunohistochemically the clinical relevance of the over-expression of the apoptosis-regulating proteins p53 and bcl-2 in a homogeneous series of 149 laryngeal squamous-cell carcinomas. p53 was over-expressed in 75 cases and bcl-2 in 39 cases. p53 and bcl-2 co-expression was found in