Effect of antianaphylactic agents on substance-P induced histamine release from rat peritoneal mast cells

✍ Scribed by H. Hachisuka; H. Nomura; F. Sakamoto; O. Mori; K. Okubo; Y. Sasai

• Publisher: Springer-Verlag
• Year: 1988
• Tongue: English
• Weight: 425 KB
• Volume: 280
• Category: Article
• ISSN: 0340-3696
• DOI: 10.1007/bf00456847

✦ Synopsis

Substance P is known to be a potent histamine liberator for mast cells. The influence of antianaphylactic agents, disodium cromoglycate (DSCG), ketotifen, and tranilast was studied on substance-P and compound 48/80-induced histamine release from rat peritoneal mast cells. Substance-P induced histamine release was inhibited by these agents, while compound 48/80-induced histamine release was not inhibited by tranilast. Our findings suggest that these antianaphylactic agents are assumed to be effective for cutaneous diseases which might be concerned with substance P and histamine.