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Effect of an estrogen antagonist on development of blastocysts and implantation in the hamster

✍ Scribed by Sengupta, Jayasree ;Paria, Bibhas C. ;Manchanda, S. K.

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
368 KB
Volume
225
Category
Article
ISSN
0022-104X

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✦ Synopsis

CI 628 citrate, an estrogen antagonist, was given as a single intraluminal injection (5 micrograms) on day 3 to ovariectomized, progesterone-treated hamsters. This significantly reduced embryo cleavage rate, transformation of morula into blastocyst, and completely inhibited implantation. The effects of the drug could be reversed by estradiol-17B (1 microgram) but not estradiol-17 alpha (1 microgram) injected intraluminally with CI 628 citrate. Our finding suggests a role of estrogen present in hamster preimplantation embryo in the triggering of embryonic differentiation and implantation of the blastocyst.

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