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Effect of amphotericin B on the lipids of yeast cells ofSporothrix schenckii

✍ Scribed by Júnia Soares Hamdan; Agnes Kiesling Casali

Publisher
Springer Netherlands
Year
1996
Tongue
English
Weight
558 KB
Volume
136
Category
Article
ISSN
0301-486X

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✦ Synopsis

Yeast cells of five strains ofSporothrix schenckii were obtained for partial analysis of lipid composition. Quantitative analysis of lipids and sterols were completed, as well as qualitative analysis of sterols by thin layer chromatography and by ultraviolet spectra. These determinations were made on cells cultured in the absence and presence of amphotericin B at sub-MIC (minimum inhibitory concentration) levels. Marked alterations in lipid content were observed in the amphotericin B-treated cells. The major alterations were the reduction of total lipid (18.7-57.6%) and sterols (48.5-96.7%) after exposure to the polyenic antibiotic. It is concluded that amphotericin B altered the lipid profiles, especially sterols ofS. schenckii.

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