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Effect of allopurinol and oxipurinol on pyrimidine synthesis in cultured human fibroblasts

โœ Scribed by William N. Kelley; Thomas D. Beardmore; Irving H. Fox; Jean C. Meade

Book ID
115770869
Publisher
Elsevier Science
Year
1971
Tongue
English
Weight
555 KB
Volume
20
Category
Article
ISSN
0006-2952

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Pyrimidine excretion by cultured fibrobl
Pyrimidine excretion by cultured fibroblasts: Effect of mutational deficiency in pyrimidine salvage enzymes
โœ Teh-Sheng Chan; Mark Meuth; Howard Green ๐Ÿ“‚ Article ๐Ÿ“… 1974 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 340 KB

## Abstract In cultured fibroblasts, a mutation resulting in deficiency of a pyrimidine salvage enzyme leads to excretion of related pyrimidines. For example, absence of thymidine kinase led to loss of thymidine and deoxyuridine, and absence of deoxycytidine kinase to loss of deoxyuridine. Both wil