✦ LIBER ✦

Effect of alginate on innate immune activation of macrophages

✍ Scribed by Dong Yang; Kim S. Jones

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 277 KB
Volume: 90A
Category: Article
ISSN: 1549-3296
DOI: 10.1002/jbm.a.32096

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✦ Synopsis

Abstract

Alginate, a natural polysaccharide, has been widely used in tissue engineering and drug delivery, butlike other biomaterials, it causes inflammation by unknown mechanisms. We hypothesized that alginate would stimulate innate immune responses through macrophage receptors. In this study, we showed that sodium alginate induced activation of macrophage‐like cells (RAW264.7) through the NF‐κB pathway. Production of proinflammatory cytokines, such as IL‐1β, IL‐6, IL‐12, and TNF‐α was time and dose‐dependent. Treatment with alginate solution caused responses that closely paralleled stimulation by lipopolysaccharide in timing and magnitude. These data suggest that sodium alginate causes innate immune responses through NF‐κB activation and likely activates the same pathways as pathogen recognition. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009

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