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Effect of age and disease on two drug binding proteins: Albumin and α-1-acid glycoprotein

✍ Scribed by J. Woo; H.S. Chan; K.H. Or; M. Arumanayagam

Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
696 KB
Volume
27
Category
Article
ISSN
0009-9120

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✦ Synopsis

The influence of age and disease on serum albumin and a-lacid glycoprotein was studied in 126 subjects (69 M, 57 F) presenting with tuberculosis and after recovery. Albumin concentration fell with age in both disease and healthy states, and a-lacid glycoprotein concentration rose with age in the healthy state. Age-related differences were less marked in the disease state. During recovery from illness, serum albumin concentration rose and a-l-acid glycoprotein concentration fell. The mean concentration difference in the latter was lower in the older age groups. The clinical consequences of changes in binding protein concentrations as a result of ageing and disease need to be studied further for individual drugs.

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