This review addresses the possible role of the insulin-like growth factor (IGF)axis in normal glucose homoeostasis and in the etiopathogenesis of type 2 diabetes. IGF-I, a peptide hormone, shares amino acid sequence homology with insulin and has insulin-like activity; most notably, the promotion of
โฆ LIBER โฆ
Effect of advanced glycation endproducts on the secretion of insulin-like growth factor-I and its binding proteins: role in osteoblast development
โ Scribed by A. D. McCarthy; S. B. Etcheverry; A. M. Cortizo
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 284 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0940-5429
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Insulin-like growth factor binding protein (IGFBP)-3 effects proliferation and differentiation of numerous cell types by binding to insulin-like growth factors (IGF) and attenuating their activity or by directly affecting cells in an IGFindependent manner. Consequently, IGFBPs produced by specific c