A previous report indicated that the tricyclic antidepressants imipramine and amitriptyline markedly increased plasma prolactin levels in man. We found no increases after acute or chronic treatment with either drug in usual clinical doses. The results indicate that blockade of serotonin reuptake doe
Effect of adjunctive paroxetine on serum levels and side-effects of tricyclic antidepressants in depressive inpatients
β Scribed by S. Leucht; H. -J. Hackl; W. Steimer; D. Angersbach; R. Zimmer
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 45 KB
- Volume
- 147
- Category
- Article
- ISSN
- 0033-3158
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## Abstract ## Objective To examine the relative tolerability and side effect profile of tricyclic antidepressants and selective serotonin reuptake inhibitors in older depressed people. ## Methods A systematic literature search generated 37 randomised controlled trials of TCAs and SSRIs of which
Paroxetine improve the quality of sleep and the ease of waking up on subjective measures of sleep (the LSEQ). Dothiepin in contrast improved the ease of getting to sleep, but caused a reduced quality of sleep and a `hangover' eect the next morning.