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Effect of adipic dihydrazide modification on the performance of collagen/hyaluronic acid scaffold

✍ Scribed by Ling Zhang; Yumei Xiao; Bo Jiang; Hongsong Fan; Xingdong Zhang

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
446 KB
Volume
9999B
Category
Article
ISSN
1552-4973

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✦ Synopsis

Abstract

Collagen and hydrazide‐functionalized hyaluronic acid derivatives were hybridized by gelating and genipin crosslinking to form composite hydrogel. The study contributed to the understanding of the effects of adipic dihydrazide modification on the physicochemical and biological properties of the collagen/hyaluronic acid scaffold. The investigation included morphology observation, mechanical measurement, swelling evaluation, and collagenase degradation. The results revealed that the stability of composites was increased through adipic dihydrazide modification and genipin crosslinking. The improved biocompatibility and retention of hyaluronic acid made the composite material more favorable to chondrocytes growing, suggesting the prepared scaffold might be high potential for chondrogenesis. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2010

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