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Effect of acyclic pyrimidines related to 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine on herpes viruses

โœ Scribed by Beauchamp, Lilia M.; Serling, Barbara L.; Kelsey, John E.; Biron, Karen K.; Collins, Peter; Selway, John; Lin, Jung-Chung; Schaeffer, Howard J.


Book ID
120060804
Publisher
American Chemical Society
Year
1988
Tongue
English
Weight
913 KB
Volume
31
Category
Article
ISSN
0022-2623

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Effect of combinations of difluoromethyl
โœ Joanne Rush; John Mills ๐Ÿ“‚ Article ๐Ÿ“… 1987 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 458 KB

Both the nucleoside analog 9[(1,3-dihydroxy-2-propoxy)methyl]guanine (ganciclovir; DHPG) and the polyamine synthesis inhibitor difluoromethylornithine (DFMO) have been reported to inhibit replication of cytomegalovirus (CMV) in vitro. In these studies, DHPG inhibited human CMV replication at concent