Effect of acute hypoxia on brain-sensitivity and metabolism of barbiturates in mice

✍ Scribed by Irwin Baumel; John J. DeFeo; Harbans Lal

• Publisher: Springer
• Year: 1970
• Tongue: English
• Weight: 274 KB
• Volume: 17
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00402709

✦ Synopsis

Acute exposure of mice to hypobaric hypoxia, or reduced oxygen at normal pressure, markedly potentiated barbiturate-induced hypnosis. The mice showed lower body concentration of pentobarbital on awakening and reduced rate of pentobarbital disappearance from the body during exposure to the hypoxie environment. These data suggest that acute exposure to hypoxia depresses in rive metabolism of pentobarbital and enhances CI~S sensitivity to the barbiturates.