Alterations in brain sensitivity and barbiturate metabolism unrelated to aggression in socially deprived mice

Effect of acute hypoxia on brain-sensiti

Effect of acute hypoxia on brain-sensitivity and metabolism of barbiturates in mice

✍ Irwin Baumel; John J. DeFeo; Harbans Lal 📂 Article 📅 1970 🏛 Springer 🌐 English ⚖ 274 KB

Acute exposure of mice to hypobaric hypoxia, or reduced oxygen at normal pressure, markedly potentiated barbiturate-induced hypnosis. The mice showed lower body concentration of pentobarbital on awakening and reduced rate of pentobarbital disappearance from the body during exposure to the hypoxie en