Effect of acute and chronic cholinesterase inhibition on biogenic amines in rat brain
โ Scribed by H. Soininen; L. Unni; S. Shillcutt
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 612 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0364-3190
No coin nor oath required. For personal study only.
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Pyrroxan (20 mg/kg, i.p.) , a new potential antianxiety agent, increased brain norepinephrine (NE) turnover in rats, reflecting a possible central e-adrenergic receptor blocking activity, in contrast, chlordiazepoxide (20 mg/kg, i.p.), a widely used antianxiety agent, did not alter the NE turnover.
MF-268 bitartrate [(3a S, 8a R)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol[8-(cis2,-6-dimethyl-morpholin-4-yl)octyl]-carbamate L-bitar- trate hydrate; Mediolanum Farmaceutici, Milan, Italy] is a pseudo-reversible carbamate-type cholinesterase inhibitor (ChEI) which interacts wi