Effect of acute and chronic administration of U50,488, a kappa opioid receptor agonist, in 6-OHDA-lesioned rats chronically treated with levodopa
✍ Scribed by C Marin; J Bové; M Bonastre; E Tolosa
- Book ID
- 117100920
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 378 KB
- Volume
- 183
- Category
- Article
- ISSN
- 0014-4886
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The present study was designed to investigate the effect of U-50, 488H, a highly selective kappa opioid agonist, on ipsilateral and contralateral circling behavior induced by methamphetamine and by apomorphine, respectively. U-50, 488H (3.2-10 mg/kg IP) by itself failed to induce either ipsilateral
## Abstract In rats bearing unilateral 6‐hydroxydopamine (6‐OHDA) lesions of the dopaminergic nigro‐striatal neurons, a single administration of a D‐2 agonist (LY 17155) potentiates the contralateral turning induced by a D‐1 agonist (SKF 38393). To identify the neural substrate of this form of sens